BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Teamup Solutions AG//Teamup Calendar//EN CALSCALE:GREGORIAN METHOD:PUBLISH DESCRIPTION:Séminaires / soutenance-0 X-WR-CALDESC:Séminaires / soutenance-0 X-WR-CALNAME:Séminaires/soutenances du LIPhy X-PUBLISHED-TTL:PT15M SUMMARY:Séminaires/soutenances du LIPhy BEGIN:VTIMEZONE TZID:Europe/Paris LAST-MODIFIED:20251211T094730Z TZURL:https://www.tzurl.org/zoneinfo-outlook/Europe/Paris X-LIC-LOCATION:Europe/Paris BEGIN:DAYLIGHT TZNAME:CEST TZOFFSETFROM:+0100 TZOFFSETTO:+0200 DTSTART:19700329T020000 RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=-1SU END:DAYLIGHT BEGIN:STANDARD TZNAME:CET TZOFFSETFROM:+0200 TZOFFSETTO:+0100 DTSTART:19701025T030000 RRULE:FREQ=YEARLY;BYMONTH=10;BYDAY=-1SU END:STANDARD END:VTIMEZONE BEGIN:VEVENT UID:TU1852343845 DTSTAMP:20260413T075737Z SUMMARY:Statuts et rôles des femmes dans la Préhistoire (Claudine Cohen ( EHESS)) DESCRIPTION:Who: Claudine Cohen (EHESS)\n\nLongtemps ignorée ou réduite à quelques clichés sexistes\, la place des femmes dans les sociétés pa léolithiques et néolithiques fut longtemps le reflet d’une vision trad itionnelle héritée du XIXe siècle. À partir des années 1970\, sous l ’impulsion des mouvements féministes anglo-saxons\, il est apparu indis pensable de redonner existence et visibilité à toute une moitié oublié e de l’humanité préhistorique. Depuis quelques décennies ces nouvelle s problématiques ont été ouvertes en France. Au-delà des professions d e foi radicales et des figures magnifiées de la Déesse ou de la Matriarc he\, de nouvelles enquêtes archéologiques\, ethnographiques\, expérimen tales\, ont nourri des questionnements neufs. Les approches du genre en pr éhistoire ouvrent aujourd’hui sur une vision plus complexe et nuancée de la diversité des statuts et des rôles féminins au long des temps pr éhistoriques\, contribuant ainsi à faire de la préhistoire une science sociale à part entière.\n\nClaudine Cohen est historienne et philosophe des sciences. Ses recherches portent sur l'histoire de la géologie\, de l a paléontologie et les représentations de la Préhistoire. Elle s’int éresse tout particulièrement aux représentations de l’évolution huma ine\, à la question de la place des femmes dans la préhistoire\, et aux approches et interprétations de l'art paléolithique. Elle est Professeur des Universités\, Directrice d'Etudes à l'Ecole de Hautes Etudes en Sci ences Sociales (Paris) Centre de Recherches sur les Arts et le Langage\, e t à l'EPHE/ PSL\, laboratoire Biogéosciences.\n\nParmi ses ouvrages sur le sujet : \n– *La Femme des Origines. Images de la femme dans la préh istoire occidentale*. Paris\, Belin Herscher \\[2003\\] 2021\n\n– *Femme s de la préhistoire*\, Paris\, Belin 2016 – réédition poche Texto Tal landier 2021\n\n*– Nos ancêtres dans les arbres*\, *Penser l'évolution humaine* Paris\, ed. du Seuil 2021\n\n*–* Dernier livre paru : *Aux ori gines de la domination masculine\,* Paris\, ed. Passés/composés septembr e 2025\n\nContact: Romain Mari\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251013T140000 DTEND;TZID=Europe/Paris:20251013T150000 CREATED:20250328T083348Z LAST-MODIFIED:20250925T084159Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1852343845 X-TEAMUP-WHO:Claudine Cohen (EHESS) END:VEVENT BEGIN:VEVENT UID:TU1957081832 DTSTAMP:20260413T075737Z SUMMARY:CO2 capture: a (rapid) overview (Elise Lorenceau (MODI\, LIPhy)) DESCRIPTION:Who: Elise Lorenceau (MODI\, LIPhy)\n\nIn this seminar\, I will explain what lies behind the acronym CCUS (Carbon Capture Utilisation and Storage technologies)\, with a particular focus on carbon capture.\n\nTo do so\, I will describe: i) why CO2 capture and CCUS have been implemented ii) the different types of existing industrial facilities for CO2 capture iii) the chemical methods for CO2 capture iv) the energy and monetary cos ts associated with CO2 and v) very briefly\, the policies put in place to promote and ensure the long-term economic viability of CCUS facilities.\n\ n CATEGORIES:Séminaires internes CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251016T110000 DTEND;TZID=Europe/Paris:20251016T120000 CREATED:20250923T080415Z LAST-MODIFIED:20251110T132538Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1957081832 X-TEAMUP-WHO:Elise Lorenceau (MODI\, LIPhy) END:VEVENT BEGIN:VEVENT UID:TU1966490299 DTSTAMP:20260413T075737Z SUMMARY:[Young Researchers Only]: Algae and bacterial love: Optimization of microalgae biosynthesis via controlled algal-bacterial symbiosis || Inte rfacial fluctuations in active phase separation (Rand ASSWAD - (PhD\, BIOP ) || Liheng YAO - (PostDoc\, PSM)) DESCRIPTION:Who: Rand ASSWAD - (PhD\, BIOP) || Liheng YAO - (PostDoc\, PSM) \n\n**Algae and bacterial love: Optimization of microalgae biosynthesis vi a controlled algal-bacterial symbiosis**\n\n*Rand ASSWAD - (PhD\, BIOP)*\n \nMicroalgae are promising biofactories for sustainable biofuel production \, offering high yields and low environmental impact. When cultivated in m icrobial consortia\, their productivity can be enhanced through cooperativ e interactions with bacteria that supply essential metabolites. However\, controlling such synthetic co-cultures in continuous bioreactors remains c hallenging due to their nonlinear and coupled dynamics. \nIn this work\, we present our mathematical model of an optogenetically-regulated algal– bacterial consortium and explore optimal strategies to maximize productivi ty. Using tools from optimal control to multi-objective optimization\, we investigate how dynamic and steady-state inputs can be tuned to improve ef ficiency\, robustness\, and process performance.\n\n---\n\n**Interfacial f luctuations in active phase separation**\n\n*Liheng YAO - (PostDoc\, PSM)* \n\nWhile equilibrium interfaces can be described to leading order using c apillary wave theory with a positive surface tension\, interfaces in activ e systems exhibit exotic behaviour that fall out of this framework. For ex ample\, certain active systems have long-lived bubbles in the dense phase that do not dissolve until their expulsion from the bulk liquid. In this t alk I will review the various quantifications of surface tension that are equivalent in equilibrium but inequivalent in active systems. I will then discuss some implications of negative surface tensions\, and their implica tions on phase transitions in active systems.\n\n LOCATION:Conference Room (Liphy) CATEGORIES:Séminaire des non-permanents CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251017T104500 DTEND;TZID=Europe/Paris:20251017T120000 CREATED:20251008T090454Z LAST-MODIFIED:20251120T080431Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1966490299 X-TEAMUP-WHO:Rand ASSWAD - (PhD\, BIOP) || Liheng YAO - (PostDoc\, PSM) X-TEAMUP-WHERE:Conference Room (Liphy) ATTACH:https://files.teamup.com/16073145/attachment/01K7EG3CT0E3NXT2M564MVC TR2/Li_portrait.jpg?hash=800c9790bdccc8e6d3dda3c44975b9703335143f83bfdc7ad 917471f3f01193c ATTACH:https://files.teamup.com/16073145/attachment/01K7HDJWPDHWZATZAYCKGBA BYE/abstract_pic.png?hash=e28f6b8531fde818d186a1af81d3c32b01501fbb6ed657f5 1dbd4a99226a26d0 ATTACH:https://files.teamup.com/16073145/attachment/01K7HDJWQ1PPH5PSM4MMV7B ERQ/Rand_portrait.jpg?hash=dc71db31527ed17e00e65fe4031f36439c862ef0fe74cc5 e20174dbb81ef0af6 END:VEVENT BEGIN:VEVENT UID:TU1911078858 DTSTAMP:20260413T075737Z SUMMARY:Les financements européens (Florence Cataye\, Céline Fontant\, Is abelle Raynaud (Service Partenariat et Valorisation du CNRS)) DESCRIPTION:Who: Florence Cataye\, Céline Fontant\, Isabelle Raynaud (Serv ice Partenariat et Valorisation du CNRS)\n\nLe pôle Europe du Service Par tenariat et Valorisation du CNRS vous propose une présentation des diffé rentes possibilités de financements européens : des financements de thè ses\, post-doc aux projets collaboratifs les plus ambitieux. Afin de vous informer et de vous accompagner de manière optimale\, un temps sera dédi é aux questions et à la discussion.\n\nContact: Bahram Houchmandzadeh\n\ n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251020T110000 DTEND;TZID=Europe/Paris:20251020T120000 CREATED:20250707T081422Z LAST-MODIFIED:20250921T132837Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1911078858 X-TEAMUP-WHO:Florence Cataye\, Céline Fontant\, Isabelle Raynaud (Service Partenariat et Valorisation du CNRS) END:VEVENT BEGIN:VEVENT UID:TU1967866294 DTSTAMP:20260413T075737Z SUMMARY:An active Brownian particle at a curved interface (Vishwas Vasisht (IIT Palakkad\, India)) DESCRIPTION:Who: Vishwas Vasisht (IIT Palakkad\, India)\n\nActive systems a re self-driven entities spanning a wide range of length scales\, from micr oscopic units (e.g.\, cells and bacteria) to macroscopic organisms (e.g.\, fish and birds). They display rich interfacial dynamics\, including bound ary accumulation and clustering\, which can lead to phenomena such as moti lity-induced phase separation and biofilm formation. Although active syste ms modeled as active Brownian particles (ABPs) have been extensively studi ed near boundaries and interfaces\, the positional and orientational stati stics remains poorly understood. In this talk I will present our simulatio n results of an ABP in circular confinement that shows that its positional distribution — from the boundary toward the interior — follows a bi-e xponential profile. Near the boundary\, it decays rapidly\, transitions to a slower decay\, and eventually becomes uniform further inside. The decay length scales depend on the confinement radius: the smaller scale is prim arily controlled by translational diffusion\, while the larger scale is se t by rotational diffusivity and self-propulsion. These behaviors are captu red by two dimensionless parameters that explicitly incorporate the confin ement radius. These findings from simulations are further supported by Fok ker–Planck calculations and experiments with a single bacterium confined within a vesicle. If time allows\, I will discuss the orientational distr ibution\, showing how ABPs align along the boundary or radially outward\, with relevance to the escape problem.\n\nContact: Kirsten Martens\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251027T110000 DTEND;TZID=Europe/Paris:20251027T120000 CREATED:20251010T083023Z LAST-MODIFIED:20251021T121442Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1967866294 X-TEAMUP-WHO:Vishwas Vasisht (IIT Palakkad\, India) END:VEVENT BEGIN:VEVENT UID:TU1881900222 DTSTAMP:20260413T075737Z SUMMARY:How Min oscillations drive polar localisation of an outer membrane protein in E. coli ? (Nicolas Desprat (LPENS\, Paris)) DESCRIPTION:Who: Nicolas Desprat (LPENS\, Paris)\n\nProtein localisation is essential for a wide range of biological functions. Understanding how cer tain proteins escape the pure laws of diffusion and do not distribute them selves homogeneously within cells is a central question in living systems. We report here that polar localisation of Ag43\, an outer membrane adhesi on protein\, undergoes biased diffusion in the periplasm of *E. Coli* than ks to the oscillations of Min proteins in the cytoplasm. This discovery co uld reveal a new paradigm for the coupling of protein localisation across two distinct cellular compartments separated by a membrane.\n\nContact: Na tale Scaramozzino\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251103T110000 DTEND;TZID=Europe/Paris:20251103T120000 CREATED:20250517T132352Z LAST-MODIFIED:20250930T122025Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1881900222 X-TEAMUP-WHO:Nicolas Desprat (LPENS\, Paris) END:VEVENT BEGIN:VEVENT UID:TU1969267134 DTSTAMP:20260413T075737Z SUMMARY:PhD defence: Transfer of carbon dioxide and air through aqueous foa ms (Cécile Aprili (LIPhy\, MODI)) DESCRIPTION:Who: Cécile Aprili (LIPhy\, MODI)\n\nThis thesis presents an e xperimental study of the CO₂ transfer dynamics within foams composed of foaming solution and CO₂–N₂ mixtures. The objective is to exploit th e differences in transfer kinetics of these two gases within the foam for potential applications in CO₂ separation and storage. Previous studies h ave shown that CO₂ permeability through a single soap film – one of th e components of the foam - is roughly 50 times bigger than the permeabilit y of N₂. Thus\, soap films can be seen as selective membranes whose seri al association to form foam results in different transfer kinetics for the two gases. However\, the phenomenon is complex\, as the density of soap f ilms and the structure of the foam can evolve with time\, due to changes i n gas content inside bubbles.\n\nTo address these issues\, we experimental ly study the kinetics of CO₂ and air transfer through a foam. We propose a set of 2D (see Figure) and 3D experiments\, accompanied by theoretical and numerical modeling to characterize gas fluxes.\n\n CATEGORIES:Soutenances CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251106T140000 DTEND;TZID=Europe/Paris:20251106T173000 CREATED:20251013T072152Z LAST-MODIFIED:20251013T151625Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1969267134 X-TEAMUP-WHO:Cécile Aprili (LIPhy\, MODI) END:VEVENT BEGIN:VEVENT UID:TU1947946169 DTSTAMP:20260413T075737Z SUMMARY:How bacteria predict and anticipate the seasons (Lisa Jabbur (The J ohn Innes Centre\, UK)) DESCRIPTION:Who: Lisa Jabbur (The John Innes Centre\, UK)\n\nDo bacteria ca re about the seasons? All throughout the tree of life\, organisms have evo lved adaptive responses that allow them to deal with the seasonal variatio ns their environment undergoes every year. Usually\, they rely on day leng th (i.e. photoperiod) as an anticipatory cue of future environmental condi tions\, and particular photoperiods trigger major changes in physiology\, behaviour and/or metabolism. Migration\, flowering\, diapause and hibernat ion are examples of such responses. Despite being widespread among eukaryo tes\, the phenomenon of photoperiodism has never been seriously considered within the realm of prokaryotes\, likely due to the assumption that bacte ria generally have such short life-cycles that an elaborate mechanism to p redict the comparably slower seasonal changes would be excluded in favour of simple direct responses. In this presentation\, I will challenge this i dea by showing evidence that cyanobacteria are also capable of using photo period to anticipate the cold temperatures of winter\, and that the way th ey do this is remarkably similar to eukaryotic photoperiodism.\n\nContact: Irina Mihalcescu\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251110T110000 DTEND;TZID=Europe/Paris:20251110T120000 CREATED:20250908T153503Z LAST-MODIFIED:20250919T121952Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1947946169 X-TEAMUP-WHO:Lisa Jabbur (The John Innes Centre\, UK) END:VEVENT BEGIN:VEVENT UID:TU1957081979 DTSTAMP:20260413T075737Z SUMMARY:Mapping thermodynamically feasible metabolic states (Vivien Lecomte (PSM\, LIPhy)) DESCRIPTION:Who: Vivien Lecomte (PSM\, LIPhy)\n\nThermodynamically\, living cells are open systems\, driven out of equilibrium by input fluxes (resou rces) and output fluxes (products\, work\, waste). A central question of s ystems biology is to understand the possible internal states of a cell fro m the knowledge of input/output fluxes and other biological bounds. Chemic al reaction networks (CRNs) are now widely known for many cells and offer a quantitative framework to tackle it. A Physicist’s take of the problem consists in mapping the allowed values of internal reaction currents give n the known constraints. At stationarity\, the relation between internal r eaction currents and external ones would be purely affine if it were not f or an essential feature of biological CRNs: inside a cell\, conservation o f energy implies that reaction rates must satisfy detailed balance. The co rresponding constraint on currents\, named thermodynamic feasibility\, ren ders the internal/external currents' relation non-linear.\n\nIn this work\ , we fully characterize the space of thermodynamically feasible currents b y showing that they constitute the bounded chambers of a well-defined hype rplane arrangement. To achieve this\, we make use «geometric» concepts o f (hyper)graph theory (such as cycles and cocycles)\, that generalize the notion of Kirchoff laws to CRNs.\n\nJoint work with Sara Dal Cengio and De lphine Ropers\n\n CATEGORIES:Séminaires internes CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251113T110000 DTEND;TZID=Europe/Paris:20251113T120000 CREATED:20250923T080447Z LAST-MODIFIED:20251110T132439Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1957081979 X-TEAMUP-WHO:Vivien Lecomte (PSM\, LIPhy) END:VEVENT BEGIN:VEVENT UID:TU1882663059 DTSTAMP:20260413T075737Z SUMMARY:Predicting Cyanotoxins Concentrations In Lakes And Reservoirs Using Microbial Community Information (Nicolas Tromas (CARRTEL\, Université Sa voie Mont Blanc)) DESCRIPTION:Who: Nicolas Tromas (CARRTEL\, Université Savoie Mont Blanc)\n \nClimate change and human activities are increasing the pressure on our w ater resources\, challenging the preservation of water quality. Cyanobacte ria are naturally present at low levels in water bodies. But due to increa sed eutrophication (nutrient input from agricultural or municipal releases ) and climate change\, some cyanobacteria bloom in aquatic ecosystems. The se blooms are a considerable threat as cyanobacteria can potentially devel op and release toxins which are harmful to human and animal health. Unfort unately\, the intensity and frequency of these blooms are increasing likel y due to human activities and are already generating economic and human he alth impacts with high societal costs. Monitoring\, predicting and prevent ing blooms is therefore a priority\, but also presents a significant chall enge. Blooms are composed of a high diversity of cyanobacteria with differ ent niches preferences and dynamics. Here\, we hypothesized that blooms co uld be viewed as a biological disturbance\, measurable by their impact on the surrounding microbial community. This disturbance could take different form – from taxa composition to genes frequency - and therefore could b e used as toxic bloom biomarkers. To identify these early warning signals of a toxic bloom\, we used data generated from the Genome Canada-funded AT RAPP project\, focusing on eight lakes\, for a total of 834 metagenomes. O ur first set of analyses\, Joint Species Distribution Modeling\, aimed at improving our understanding of how toxins respond to environmental variabl es. We found that seasonality was a key variable in explaining the presenc e-absence and continued rise in cyanotoxins\, followed by ammonia and tota l phosphorus concentrations. To further examine toxins seasonal succession and evaluate toxins co-occurrence\, we ran a Latent Dirichlet Allocation. We found that certain toxins appeared earlier in the season in many lakes (microcystin-LR and –LY)\, and were replaced by a different community o f toxins by summer (microcystin-LA\, anabaenopeptins). To finally predict total microcystin concentrations and the time until toxicity reached the W HO guideline of >\;1 ug/L\, we used of Bayesian Additive Regression Tree s with microbial data as predictive variables. All observed species of cya nobacteria (Spearman correlation of observed vs. predicted values = 0.84) or the top 500 non-cyanobacterial species (correlation = 0.83) showed simi lar results. Predictions of the time until the WHO guideline was reached w ere more uncertain (correlation = 0.7 using cyanobacterial taxa or 0.67 us ing non-cyanobacteria)\, but still significant.\n\nContact: Natale Scaramo zzino\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251117T110000 DTEND;TZID=Europe/Paris:20251117T120000 CREATED:20250519T083921Z LAST-MODIFIED:20251117T131923Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1882663059 X-TEAMUP-WHO:Nicolas Tromas (CARRTEL\, Université Savoie Mont Blanc) END:VEVENT BEGIN:VEVENT UID:TU1963645169 DTSTAMP:20260413T075737Z SUMMARY:Cells growing in soft confined environments: from spheroids to soil bacteria (Willy Bonneuil (Institut de Physique de Rennes)) DESCRIPTION:Who: Willy Bonneuil (Institut de Physique de Rennes)\n\nSpheroi ds are a blooming experimental model of human tissues that allows real-tim e observation of cells in three dimensions and under physiologically relev ant mechanical stimuli. Mechanically\, they are soft porous spheres of low permeability. They most often protrude from a substrate to which they are attached—the floor of cell culture chambers. I show in a theoretical an d numerical study how this partial confinement\, fluid flow in the culture chamber\, and tissue deformation combine to limit\, or promote\, spheroid growth.\n\nBacteria are known to be beneficial to the structure and funct ion of soil\, in that their action increases porosity and pore connectivit y. I investigate through microfluidics experiments the role of micromechan ical interactions between growing bacterial microcolonies and a granular m edium whose particles are mobile. Those experiments show that growth-induc ed pressure in colonies that are adjacent to grains deforms "soft" grain c hains. I propose that the viscous relaxation of those growth stresses can induce a "granular respiration" where grain chains are compressed before r elaxing into a new mechanical equilibrium after bacterial growth has ended .\n\nContact: Jocelyn Etienne\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251120T110000 DTEND;TZID=Europe/Paris:20251120T120000 CREATED:20251003T093751Z LAST-MODIFIED:20251110T093304Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1963645169 X-TEAMUP-WHO:Willy Bonneuil (Institut de Physique de Rennes) END:VEVENT BEGIN:VEVENT UID:TU1980566189 DTSTAMP:20260413T075737Z SUMMARY:PhD defence: Optimised 3D fluorescence and autofluorescence imaging of sub-microscopic dentin porosity in human dentin (Seunghwan Lee (OPTIMA \, LIPhy)) DESCRIPTION:Who: Seunghwan Lee (OPTIMA\, LIPhy)\n\nThis study aims to estab lish a methodology to enhance three-dimensional (3D) visualisation of dent in porosity. Dentin is a key feature to understand the mechanical and biol ogical properties of human teeth and could serve as a pathological indicat or. Despite its significance\, the 3D structure of dentin porosity remains poorly described due to the technical challenges of volumetric imaging wi th nanometre-scale resolution and the strong light scattering properties o f dentin. To overcome these challenges\, we developed a protocol that comb ines sub-wavelength sample surface preparation\, refractive index-matched staining\, and two-photon microscopy (TPM). The protocol was evaluated by expert visual assessment\, using the contrast between porosity and surroun ding tissue\, as well as optical aberration effects as discriminating crit eria. Subsequently\, we developed image quality analysis metrics that refl ect expert perception. Overall\, our study provides a quantitative framewo rk to assess dentin porosity imaging depth limits and an approach that ach ieves an 8-fold greater imaging depth compared with standard confocal lase r scanning microscopy (CLSM). Another focus of our research is demonstrati ng the value of autofluorescence imaging for dentin porosity. In elderly p atients\, mineral crystal deposition causes porosity occlusion\, which imp edes staining medium infiltration. Simultaneous autofluorescence acquisiti on enabled visualisation of the occluded porosity without additional stain ing or instrumentation. We further demonstrated the applicability of our 3 D porosity analysis through a case study of a rare disease: dentinogenesis imperfecta (DI). A tooth from a patient with type I DI was processed with our sample preparation protocol. Pathological dentin porosity was mapped across the entire dentin using CLSM\, and its 3D structure was further vis ualised in selected regions by TPM. Structural abnormalities of dentin por osity revealed new insights into pathological dentinogenesis in DI. These advances highlight the potential of our protocol for dentin porosity studi es in future dental research.\n\n CATEGORIES:Soutenances CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251121T100000 DTEND;TZID=Europe/Paris:20251121T110000 CREATED:20251030T140909Z LAST-MODIFIED:20251104T105518Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1980566189 X-TEAMUP-WHO:Seunghwan Lee (OPTIMA\, LIPhy) END:VEVENT BEGIN:VEVENT UID:TU1980635212 DTSTAMP:20260413T075737Z SUMMARY:Exploring Ion and Heat Transport Across Confined Interfaces: Wettin g Films and Thermal Anti-Bubbles (Aymeric Allemand (Université Libre de B ruxelles\, Belgium)) DESCRIPTION:Who: Aymeric Allemand (Université Libre de Bruxelles\, Belgium )\n\nDuring this seminar\, I will present my research on transport phenome na within confined wetting films and on interfacial heat and mass transfer in encapsulated Leidenfrost drops.\n\nMy PhD work focuses on ion transpor t in thin wetting films. Using an experimental approach\, we developed a s ystem that allows continuous control of the film confinement as it spontan eously forms on a hydrophilic substrate. Ionic transport was then investig ated through electrical conductance measurements. Complementary molecular dynamics simulations provided access to quantities that are experimentally inaccessible and allowed us to rationalize the observed behavior by intro ducing an additional friction force between the ions and the solid substra te.\n\nIn the second part of the talk\, I will describe thermal antibubble s formed under microgravity conditions\, which can be seen as drainage-fre e encapsulated Leidenfrost drops. The investigation of these systems revea led distinct heat transfer mechanisms compared to the classical liquid–l iquid Leidenfrost effect\, shedding new light on the stability and dynamic s of gas–liquid interfaces.\n\nContact: Romain Lhermerout\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251124T110000 DTEND;TZID=Europe/Paris:20251124T120000 CREATED:20251030T154159Z LAST-MODIFIED:20251110T110951Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1980635212 X-TEAMUP-WHO:Aymeric Allemand (Université Libre de Bruxelles\, Belgium) END:VEVENT BEGIN:VEVENT UID:TU1980565970 DTSTAMP:20260413T075737Z SUMMARY:PhD defence: Optical Analysis of Nav1.2 Function in Neurons: Physio logical Roles and Pathological Implications in SCN2A Loss-of-Function Chan nelopathies (Fatima Abbas (OPTIMA\, LIPhy)) DESCRIPTION:Who: Fatima Abbas (OPTIMA\, LIPhy)\n\nThe SCN2A gene encodes th e voltage-gated sodium channel Nav1.2\, predominantly expressed in the axo n initial segment (AIS) of excitatory neurons in the cortex\, vital for th e generation and back-propagation of action potentials. Pathogenic variant s of SCN2A are associated with a wide spectrum of neurodevelopmental disor ders\, including autism and intellectual disability\, commonly linked to N av1.2 loss-of-function (LoF). In this thesis we investigated the pathophys iology underlying these mutations in two SCN2A LoF mouse models with featu res of autistic-like behavior compared to the wild-type mouse: a heterozyg ote knock-out (Scn2a+/-)\, and a knock-in (Scn2a+/L1314P) carrying a patie nt-derived missense variant. We used an approach combining whole-cell patc h clamp recordings with ultrafast optical imaging of sodium (Na+)\, calciu m (Ca2+)\, and membrane potential (Vm) in cortical slices to resolve the s ubmillisecond dynamics (50-100 µs scale) of AP generation in layer 5 pyra midal neurons. Our analyses reveal mutation-specific alterations in sodium and calcium influx\, together with abnormal modulation of potassium chann els\, particularly Kv1. Complementary imaging in distal dendritic compartm ents shows that Nav1.2 defects remodel rather than abolish the ability to generate regenerative calcium signals despite perturbations at the AIS lev el\, indicating the presence of partial regulatory mechanisms in response to axonal alterations. Altogether\, these findings shed light on the diver gent functional consequences of SCN2A LoF mutations and challenges the wid ely accepted concept of GoF versus LoF which is applied to classify channe lopathies. By combining our cutting-edge techniques with age-specific anal yses and targeted pharmacological interventions\, we establish a novel app roach for physiological phenotyping and drug assessment at the subcellular level\, offering valuable insights into complex genotype-phenotype correl ations toward therapeutic strategies targeted to specific patterns of Nav1 .2 dysfunctions in SCN2A-related disorders.\n\n CATEGORIES:Soutenances CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251124T140000 DTEND;TZID=Europe/Paris:20251124T150000 CREATED:20251030T140842Z LAST-MODIFIED:20251105T160806Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1980565970 X-TEAMUP-WHO:Fatima Abbas (OPTIMA\, LIPhy) END:VEVENT BEGIN:VEVENT UID:TU1992325612 DTSTAMP:20260413T075737Z SUMMARY:[Young Researchers Only]: MorphoChip: Cell Quadruplets To Study Cel l Intercalation || HCERES Discussion (Daniel SELMA HERRADOR - (PhD\, Micr oTiss) || HCERES Discussion For Non-Permanents) DESCRIPTION:Who: Daniel SELMA HERRADOR - (PhD\, MicroTiss) || HCERES Discus sion For Non-Permanents\n\n**MorphoChip: Cell Quadruplets To Study Cell In tercalation**\n\n*Daniel SELMA HERRADOR - (PhD\, MicroTiss)*\n\nCell inter calation\, or T1 transition\, is a central morphogenetic process in which cells exchange neighbors to shape tissues while preserving overall integri ty. It involves active and passive mechanisms such as cell crawling and ac tomyosin pulsations\, respectively\, but the physical working principle re mains unknown. Typical *in vivo* studies (e.g.\, *Drosophila*) comprise hi ghly complex environments to study these isolated events\, whereas *in sil ico* models require experimental validation. Here\, we introduce an *in vi tro* assay using four-cell assemblies—cell quadruplets—that replicate the minimal tissue architecture for T1 transitions\, setting a compromise between biological relevance and access to statistical analysis. Experimen ts prove that cell intercalation rates can be tuned through passive pertur bations\, and that novel associated energy landscapes can be extracted per condition\, consistent with cell–vertex models.\n\n---\n\n**HCERES Eval uation – What Is It &\; Why It Is Important For Non-Permanents**\n\nT he **HCERES** (*High Council for the Evaluation of Research and Higher Edu cation*) is the national body that periodically evaluates universities\, r esearch labs\, and doctoral schools in France. Its visiting committee revi ews research quality\, training conditions\, supervision\, career support\ , working environment\, and the overall functioning of the lab.\n\nSince t he HCERES visit will take place in the first week of December\, the semina r will be held exceptionally on a Tuesday to gather the concerns\, priorit ies\, and suggestions of the non-permanent members of the lab.\n\n LOCATION:Conference Room (Liphy) CATEGORIES:Séminaire des non-permanents CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251125T104500 DTEND;TZID=Europe/Paris:20251125T120000 CREATED:20251119T072629Z LAST-MODIFIED:20251128T091436Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1992325612 X-TEAMUP-WHO:Daniel SELMA HERRADOR - (PhD\, MicroTiss) || HCERES Discussion For Non-Permanents X-TEAMUP-WHERE:Conference Room (Liphy) ATTACH:https://files.teamup.com/16073145/attachment/01KADG3YMVRFXRH5G93MQ14 MMN/pic_Daniel_Selma.jpeg?hash=b972e9f56af531fbce48c11a5ebba9eed9549729ca0 e760bcbbd446e9610deb9 ATTACH:https://files.teamup.com/16073145/attachment/01KATK36FDXMEE1FEF5CFVR 7C8/abs_DanielSelma.png?hash=8bf32aa939ddcaecc72123635a82e2b24b2afef109fda 20f95cdde84c8293c70 END:VEVENT BEGIN:VEVENT UID:TU1991135050 DTSTAMP:20260413T075737Z SUMMARY:On balanced growth and precision control in bacteria (Suckjoon Jun (UC San Diego\, USA)) DESCRIPTION:Who: Suckjoon Jun (UC San Diego\, USA)\n\nTwo core principles u nderlie bacterial physiology. The first\, articulated in the 1950s\, is *b alanced growth* — the idea that all cellular components increase at the same rate. The second is *precision control* — the cell’s ability to c oordinate spatial and temporal events\, such as DNA replication and divisi on\, with remarkable accuracy. Reconciling these two principles poses a co nceptual challenge rarely addressed in biology textbooks. In this talk\, I will show how bacteria achieve physiological homeostasis and precise regu lation under balanced growth\, revealing mechanisms fundamentally differen t from those emphasized in eukaryote-centric models.\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251126T110000 DTEND;TZID=Europe/Paris:20251126T120000 CREATED:20251117T151949Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1991135050 X-TEAMUP-WHO:Suckjoon Jun (UC San Diego\, USA) END:VEVENT BEGIN:VEVENT UID:TU1985561611 DTSTAMP:20260413T075737Z SUMMARY:Moving without motors: Amoeboid cell migration and shape dynamics d riven by actin polymerization (Winfried Schmidt (ECCEL\, LIPhy)) DESCRIPTION:Who: Winfried Schmidt (ECCEL\, LIPhy)\n\nMammalian cell motilit y is essential for many physiological and pathological processes\, such as embryonic development\, wound healing\, and cancer metastasis. Cells have developed the amoeboid migration mode\, which is characterized by large\, dynamic shape deformations. This strategy allows cells to move rapidly an d in the absence of strong adhesion across a variety of different environm ents\, including two-dimensional confinement\, three-dimensional matrix\, and bulk fluids. Molecular motors\, such as myosin\, are traditionally con sidered essential for cell polarization. Here\, a model of an amoeboid cel l is analyzed both analytically and numerically. It is shown that actin po lymerization alone is sufficient to trigger both cell polarity and motilit y\, in line with recent experiments on T-lymphocytes showing that inhibiti on of molecular motors does not significantly affect motility. Depending o n parameter values\, the cells exhibit straight\, circular\, or even chaot ic trajectories. A similar variety of motion is observed across multiple m otile cells. These findings open up a new perspective on amoeboid motility \, providing a scenario for the onset of polarity\, migration\, and dynami cal cell shape changes without contractile activity.\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251127T110000 DTEND;TZID=Europe/Paris:20251127T120000 CREATED:20251107T141546Z LAST-MODIFIED:20251114T081121Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1985561611 X-TEAMUP-WHO:Winfried Schmidt (ECCEL\, LIPhy) END:VEVENT BEGIN:VEVENT UID:TU1962398465 DTSTAMP:20260413T075737Z SUMMARY:Bridging the scales in biological tissues (Nicolas Cuny (Universit é de Genève\, Switzerland)) DESCRIPTION:Who: Nicolas Cuny (Université de Genève\, Switzerland)\n\nBio logical tissues are active materials exhibiting complex behaviour at the m acroscopic scale\, allowing them to fulfill diverse biological functions. However\, the biochemical processes responsible for those original behavio urs take place at much smaller scales\, typically at the (sub)cellular lev el. This scale separation makes it challenging to adress tissues’ mechan obiology\, i.e the reciprocal interactions between biology and mechanics. In this talk\, I will introduce the active gels framework\, developped in the last two decades and that allows to describe tissues at an intermediat e mesoscopic scale as continuous materials and to integrate an effective d escription of the biochemical processes at this scale.\n\nI will first ill ustrate the interest of such a mesoscopic description by introducing an ac tive shell model that can be used to investigate the biomechanical determi nants of the larval shape in different species of cnidarians\, a family of sea animals. This model combined to quantitative imaging data reveals a f ew common mesoscopic features of larval tissue controling their shape and emphasizes the relevance of the mesoscopic scale to study shape evolution along species.\n\nIn a second time\, I will exemplify how the effect of su bcellular biological elements can be integrate in a continuous model. Base d on in vitro mechanical assays\, I will introduce a constitutive model of the endothelium tissue where it is described as an active anisotropic vis coelastic material which anisotropy is controled by the actin network orga nisation. This model recapitulates the dynamics of pressurized endothelial tubes and address the reciprocal couplings between biology and mechanics in those tissues.\n\nContact: Pierre Recho\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251201T110000 DTEND;TZID=Europe/Paris:20251201T120000 CREATED:20251001T133348Z LAST-MODIFIED:20251112T081621Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1962398465 X-TEAMUP-WHO:Nicolas Cuny (Université de Genève\, Switzerland) END:VEVENT BEGIN:VEVENT UID:TU1955082148 DTSTAMP:20260413T075737Z SUMMARY:PhD defence: Connectomic analysis of multiscale cellular networks i n mineralized tissues (Lucas Chatelain (OPTIMA\, LIPhy)) DESCRIPTION:Who: Lucas Chatelain (OPTIMA\, LIPhy)\n\nTeeth are complex orga ns sensitive to external physical perturbations (e.g.\, thermal and mechan ical) under physiological conditions. According to hydrodynamic theory\, t hese stimuli are propagated to the cell bodies of the odontoblasts and ner ve endings located in the pulp via fluid flow in dentinal porosity. This p orosity is mainly formed by long parallel microscopic tubules running from the pulp to the enamel\, but there are also secondary branches forming co nnections between tubules. These fine sub-micrometric branches are difficu lt to image over large volumes\, and their impact on the interconnections between tubules therefore remains unknown. However\, the topology and geom etry of dentin porosity determine dentin fluid flow. The mechanosensory fu nction of the tooth could therefore be more complex than currently describ ed in the literature.\n\nPorosity imaged by confocal fluorescence microsco py confirms a high density of branches and interconnections with tubules\, which varies depending on the location within the tooth. Modeling porosit y as a graph thus allowed demonstrating that dentin porosity forms a highl y connected network with topological characteristics distinct from other t ypes of biological physical networks. An in-depth analysis of biases in gr aph modeling was performed to determine margins of error on graph metrics and predict their evolution according to experimental conditions and image processing. This provides a useful framework to evaluate the statistical relevance of measurements acquired under a broader range of conditions tha n ours. The comparison of colocalized acquisitions from confocal and two-p hoton fluorescence microscopy illustrates the richness of interpretation o f graph analysis in deciphering complex phenomena. The results obtained on five samples in different anatomical regions confirmed our initial observ ations. A comparison of graph metrics and histological parameters is also proposed to facilitate transfer to biomedical research. This preliminary w ork also paves the way for more complex analyses of fluid flow simulations on graphs\, or clinical research on pathologies or treatments affecting d entinogenesis.\n\n CATEGORIES:Soutenances CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251201T133000 DTEND;TZID=Europe/Paris:20251201T170000 CREATED:20250919T125102Z LAST-MODIFIED:20251013T151614Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1955082148 X-TEAMUP-WHO:Lucas Chatelain (OPTIMA\, LIPhy) END:VEVENT BEGIN:VEVENT UID:TU1980635577 DTSTAMP:20260413T075737Z SUMMARY:From transport in channels to population evolution: how heterogenei ties shape dynamics (Arthur Alexandre (EPFL\, Switzerland)) DESCRIPTION:Who: Arthur Alexandre (EPFL\, Switzerland)\n\nIn this seminar\, I will discuss two problems where effective descriptions capture the esse ntial mechanisms at play: one from hydrodynamics and one from population g enetics.\n\nIn hydrodynamics\, Taylor dispersion describes the enhanced sp reading of particles in a fluid due to the combined effects of diffusion a nd flow. We show how this phenomenon can be understood in tortuous\, highl y corrugated channels using an effective model that captures the main tran sport properties\, providing insight into flows in porous media.\n\nIn pop ulation genetics\, the gut microbiota presents extensive genetic diversity shaped by its flow-dominated environment. Using a minimal model \\[2\\] i ncorporating flow\, diffusion\, and microbial growth that we extend to non -neutral mutations\, we show how spatial structure and advection influence the fixation of beneficial mutants. This illustrates the interplay betwee n flow\, growth\, and spatial heterogeneity in shaping microbial evolution .\n\n\\[1\\] Alexandre\, A.\, Guérin\, T. &\; Dean\, D. S. Effective d escription of taylor dispersion in strongly corrugated channels. Physical Review E 111\, 064124 (2025).\n\n\\[2\\] Labavić\, D.\, Loverdo\, C. & \; Bitbol\, A.-F. Hydrodynamic flow and concentration gradients in the gut enhance neutral bacterial diversity. Proceedings of the National Academy of Sciences 119\, e2108671119 (2022).\n\nContact: Bahram Houchmandzadeh\n\ n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251208T110000 DTEND;TZID=Europe/Paris:20251208T120000 CREATED:20251030T154246Z LAST-MODIFIED:20251105T154738Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1980635577 X-TEAMUP-WHO:Arthur Alexandre (EPFL\, Switzerland) END:VEVENT BEGIN:VEVENT UID:TU1980566828 DTSTAMP:20260413T075737Z SUMMARY:PhD defence: Self-sustained velocity waves and pattern emergence in tissues (Génésis Marquez-Vivas (Microtiss\, LIPhy)) DESCRIPTION:Who: Génésis Marquez-Vivas (Microtiss\, LIPhy)\n\nMorphogenes is integrates chemical gradients with tissue mechanics to coordinate cells across space and time. While reaction–diffusion explains many patterns\ , developing tissues can also transmit information through self-generated stresses. Here we show that confined epithelial monolayers autonomously ge nerate standing waves that provide positional landmarks and a temporal cue in the absence of external driving. We cultured MDCK monolayers on microf abricated band patterns\, performed long-term imaging\, and quantified flo w fields by particle image velocimetry. Varying the confinement length rev eals a size-dependent transition: short tissues undergo global oscillation s\, whereas longer tissues reproducibly form standing waves with fixed nod es and antinodes. Beyond this transition\, the oscillations exhibit robust intrinsic scales\, with wavelengths of hundreds of micrometers and period s of a few hours. Using spatial photoactivation and FACS\, we isolated cel ls residing at nodes and antinodes for transcriptomic profiling. Different ial expression and immunostaining revealed mechanical niches\, with specif ic protein markers forming position-locked spatial patterns that recapitul ate the wave’s length scale. Together\, these results show that a self-s ustained\, geometry-constrained oscillatory state can template spatial mol ecular identities in an otherwise uniform epithelium\, providing a tractab le route to connect mechanics\, collective migration\, and gene regulation across scales.\n\n CATEGORIES:Soutenances CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251209T140000 DTEND;TZID=Europe/Paris:20251209T150000 CREATED:20251030T141026Z LAST-MODIFIED:20251121T133138Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1980566828 X-TEAMUP-WHO:Génésis Marquez-Vivas (Microtiss\, LIPhy) END:VEVENT BEGIN:VEVENT UID:TU1980567026 DTSTAMP:20260413T075737Z SUMMARY:PhD defence: Acoustic Response of Fluid Adsorption and Transport in Nanoporous Materials (Loriane Didier (PSM\, LIPhy)) DESCRIPTION:Who: Loriane Didier (PSM\, LIPhy)\n\nFluid adsorption and trans port in nanoporous materials are central to efficient technologies with im portant energy and environmental applications. Yet\, while the structural\ , thermodynamic and transport properties of fluid in nanoporous materials are the subject of intense research\, many aspects remain poorly understoo d. In particular\, the acoustic signature of fluid confinement and adsorpt ion in nanoporous solids still needs to be deciphered and rationalized. In this thesis\, we explore the coupling at the nanoscale between fluid adso rption/transport and the acoustic properties of the host nanoporous materi al. Within the framework of statistical mechanics\, we employ molecular dy namics simulations for a prototypical nanoporous material (an all-silica z eolite) filled with methane\, carbon dioxide\, and their mixture. First\, we investigate the diffusion and permeability of these different fluids an d show that the transport coefficients display either a monotonous or non- monotonous behavior upon increasing the fluid adsorbed amount. In the case of the fluid mixtures\, we show that the miscibility/immiscibility – wi th potential nanosegregation effects – of the nanoconfined mixture play a key role. Second\, we invoke the dynamic structure factor to investigate the acoustic properties of the zeolite subjected to fluid adsorption. By identifying the sound mode\, we show that the fluid density significantly affects both the sound velocity and attenuation of the host zeolite. In pa rticular\, we develop simple physical models to rationalize the decrease i n the sound velocity and increase in the sound attenuation upon fluid adso rption. Finally\, we show that acoustic stimulation of the fluid-filled ze olite leads to a significant boost in both the fluid diffusion and permeab ility.\n\n CATEGORIES:Soutenances CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251211T133000 DTEND;TZID=Europe/Paris:20251211T143000 CREATED:20251030T141050Z LAST-MODIFIED:20251127T164852Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1980567026 X-TEAMUP-WHO:Loriane Didier (PSM\, LIPhy) END:VEVENT BEGIN:VEVENT UID:TU1991834238 DTSTAMP:20260413T075737Z SUMMARY:Decoding synaptic diversity with AI-assisted nanoscopy (Flavie Lavo ie-Cardinal (Université Laval\, Canada)) DESCRIPTION:Who: Flavie Lavoie-Cardinal (Université Laval\, Canada)\n\nSyn apses display remarkable molecular and structural diversity that underlies neuronal connectivity and brain function. Super-resolution microscopy now enables imaging of their nanoscale organization within intact circuits\, generating complex datasets that demand scalable analytical frameworks. Se lf-supervised and foundation models provide robust\, annotation-free analy sis\, capturing latent representations of synaptic architecture for tasks such as segmentation and phenotypic clustering. Leveraging these models al lows discovery of subtype-specific remodeling patterns and subtle nanoscal e activity-dependent synaptic remodelling\, advancing data-driven understa nding of synaptic diversity.\n\nContact: Aurélien Gourrier\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251217T110000 DTEND;TZID=Europe/Paris:20251217T120000 CREATED:20251118T142641Z LAST-MODIFIED:20251120T150455Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1991834238 X-TEAMUP-WHO:Flavie Lavoie-Cardinal (Université Laval\, Canada) END:VEVENT BEGIN:VEVENT UID:TU2007822880 DTSTAMP:20260413T075737Z SUMMARY:Interfacial Physics of Microfluidically Formed Monodisperse Microb ubbles (Tim Segers (University of Twente\, the Netherlands)) DESCRIPTION:Who: Tim Segers (University of Twente\, the Netherlands)\n\nPho spholipid-coated microbubbles exhibit acoustic behavior that is tightly go verned by their size and by the rheology of their stabilizing shell. In th is talk\, I will show how both properties can be precisely controlled and quantified using microfluidic production of monodisperse (functionalized ) microbubbles\, together with new optical and acoustic measurement strate gies. I will discuss microfluidic flow-focusing for generating highly un iform bubbles\, lipid phase separation in multicomponent shells\, and how these features shape bubble stability\, buckling\, and even negative surfa ce tension. I will introduce a new quasistatic interfacial rheometry metho d that combines multiwavelength optical attenuation spectroscopy with pres sure-dependent acoustic attenuation to deliver rapid\, accurate measuremen ts of bubble radius\, shell elasticity\, shell viscosity\, and the bubble surface area dependent surface tension curve. The method reveals how envir onmental conditions such as salinity and acidity affect shell mechanics\, and how these rheological insights inform nonlinear bubble dynamics\, incl uding subharmonic generation for non-invasive pressure sensing.\n\nContact : Gwennou Coupier\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251218T100000 DTEND;TZID=Europe/Paris:20251218T110000 CREATED:20251215T134308Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2007822880 X-TEAMUP-WHO:Tim Segers (University of Twente\, the Netherlands) END:VEVENT BEGIN:VEVENT UID:TU1980567244 DTSTAMP:20260413T075737Z SUMMARY:PhD defence: Movement of a buckling ultrasound contrast agent under low-frequency ultrasound excitation (Andréa Feasson (MC2\, LIPhy)) DESCRIPTION:Who: Andréa Feasson (MC2\, LIPhy)\n\nMicrorobots have held the interest of the scientific community for some decades now. Their versatil ity of application\, especially in medicine\, can explain the enthusiasm f or this field of research.\n\nThe present work focuses on the navigation o f phospholipidic microshells called ultrasound contrast agents (UCAs) via a buckling instability triggered by pressure. A potential application of t his phenomenon would be to navigate UCAs in the bloodstream for targeted d rug delivery purposes.\n\nWe studied experimentally the swimming motion of these ultrasound contrast agents under a standing wave field of ultrasoun d around 26.5 kHz for a pressure amplitude ranging from 0 to 30 kPa. This thesis aimed to determine if buckling can induce motion under ultrasound. Indeed\, in an acoustic field\, there are two main known mechanisms to cau se movement on a UCA: radiation forces and streaming. We developed an expe rimental setup allowing us to study the swimming motion separately from th e radiation forces. Using this setup\, we could indirectly link the swimmi ng motion to buckling.\n\nIn the optics of further application where the r adiation forces will be present\, we studied the coupling between the swim ming and the radiation forces. We analysed the coupling at the same freque ncy in standing waves in the same ultrasound pressure interval as previous ly.\n\n CATEGORIES:Soutenances CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251218T140000 DTEND;TZID=Europe/Paris:20251218T150000 CREATED:20251030T141119Z LAST-MODIFIED:20251119T132738Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1980567244 X-TEAMUP-WHO:Andréa Feasson (MC2\, LIPhy) END:VEVENT BEGIN:VEVENT UID:TU1980567657 DTSTAMP:20260413T075737Z SUMMARY:PhD defence: Deep learning based super-resolution for large field o f view imaging of the porosity network in dentin (Lauren Anderson (OPTIMA\ , LIPhy)) DESCRIPTION:Who: Lauren Anderson (OPTIMA\, LIPhy)\n\nImaging dentinal poros ity is currently a challenging topic in dental research. This porosity res ults from the presence of cellular processes from odontoblasts\, located i n the pulp and believed to play a key role in mechano-sensing. It consists of microscopic tubules\, interconnected with sub-microscopic branches con taining cell processes surrounded by physiological fluids. The recent obse rvation that these pore vessels form a dense network led to the realizatio n that mechanical or thermal stimuli propagation could be more complex tha n currently thought. Acquiring an accurate 3D representation of this netwo rk is therefore key to understanding tooth function. This imposes strong c onstraints on imaging resolution\, which needs to be in the 100 nm range t o visualize the smallest pores\, while achieving visualization of an entir e tooth section to take into account histology and anatomical fluctuations . This is currently beyond the reach of any existing imaging modality or i nstruments.\n\nTo achieve high-resolution (HR) visualization on the full t ooth scale\, we propose using deep learning (DL) super-resolution (SR) mod els trained on confocal fluorescence microscopy images\, the current gold- standard for 3D visualization of dentinal porosity. The principle is to ap ply SR models to restore the highest achievable optical resolution for a g iven microscope on degraded images acquired much faster by under-sampling the scan. This is achieved by training SR models using pairs of low-resolu tion (LR) and HR images. Three supervised DL models (RCAN\, FSRCNN\, pix2p ix) and one unsupervised model (CycleGAN) were selected and applied to a u nique set of experimentally paired high- and low-resolution confocal image s acquired with a pixel size increase of x2\, x4\, and x8. Training was pe rformed on input patches\, carefully selected to balance representation of different porosity feature classes. Qualitative assessment on model perfo rmance showed good results for all models at x2 degradation and CycleGAN u p to x8 degradation. Quantitative analysis of generated HR images was then performed with a set of standard similarity and distribution-based image quality assessment (IQA) metrics\, which produced contradictory results co mpared to visual assessment. This drew the need for the development of a b iology-driven evaluation based on scales\, morphology\, and connectivity o f the porosity network. A connected component analysis of 2D scales and mo rphology followed by a 3D graph network analysis of connectivity was perfo rmed. Based on a combination of all quantitative results\, CycleGAN and pi x2pix models showed good performance up to x8. CycleGAN was selected and i mproved with new training on an enriched dataset\, with the goal of traini ng a more generalizable model. Finally\, application of this newly trained model on large FOV LR acquisitions at x4 and x8 was performed\, producing 5.8 mm x 3.3 mm x 20.4 µm HR volumes.\n\nResults from this study showed great promise for the use of SR models with confocal microscopy to restore HR information from LR acquisitions. The CycleGAN and pix2pix showed good performance up to x8\, which decreased scan time by a factor of 20.3. The biology-driven assessment allowed for a better interpretation of SR model performance specific to dentin porosity features. For example\, to identi fy specific missing or false positive components\, the effects of low inte nsity features\, and non-linearities in model generation. With an improved and more generalizable CycleGAN\, a large HR FOV could be generated which \, including scan-time and model application\, provided HR outputs 8.1x fa ster than a standard HR acquisition and reduced scan time by over 300 hour s. Results from this study introduces a great potential for achieving larg e-scale HR visualization of the microscopic and sub-microscopic porosity n etwork in dentin\, working towards imaging dentin porosity in a whole toot h.\n\n CATEGORIES:Soutenances CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20251219T150000 DTEND;TZID=Europe/Paris:20251219T160000 CREATED:20251030T141153Z LAST-MODIFIED:20251104T092108Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1980567657 X-TEAMUP-WHO:Lauren Anderson (OPTIMA\, LIPhy) END:VEVENT BEGIN:VEVENT UID:TU1905245867 DTSTAMP:20260413T075737Z SUMMARY:Bubbles: how they make noise\, and how they can absorb it (Valentin Leroy (Laboratoire Matière et Systèmes Complexes\, Paris)) DESCRIPTION:Who: Valentin Leroy (Laboratoire Matière et Systèmes Complexe s\, Paris)\n\nA bubble makes a sound when it detaches. While the frequency of this sound is well understood\, there has been no consensus on what ca uses its amplitude. Although mechanisms based on shape oscillations\, init ial velocity\, neck collapse or Laplace pressure have been suggested\, the se have not been systematically verified through experimentation. Our expe riments\, with bubbles released from a nozzle or entrapped by the impact o f a drop\, show that the initial velocity scenario provides a reasonable p rediction of the sound amplitude\, over three orders of magnitude. We refi ned this scenario by describing how the bubble velocity is affected by gas exchange through the closing neck. This ``leaking bubble'' model predicts that the bubble begins to produce sound prior to detachment\, as observed experimentally. By feeding image analysis of the neck into the model\, we obtained excellent agreement between the experimental and the calculated pressure signals.\n\nBubbles can also absorb sound. A thin flexible coatin g consisting of air cavities embedded in a rubber elastomer can achieve ac oustic absorption down to the kilo-hertz range. We demonstrate this by cha racterizing a standard commercial aquarium\, identifying its resonances\, and designing an optimized bubble screen configuration that effectively re duces reflections in the 3–6 kHz range\, approaching the acoustic behavi or of an infinite open-water environment. Time-domain analysis confirms th at applying this coating significantly reduces tank reflections\, offering a practical method for improving the accuracy of underwater acoustic rese arch.\n\nContact: Benjamin Dollet\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260112T110000 DTEND;TZID=Europe/Paris:20260112T120000 CREATED:20250626T124942Z LAST-MODIFIED:20251211T082313Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1905245867 X-TEAMUP-WHO:Valentin Leroy (Laboratoire Matière et Systèmes Complexes\, Paris) END:VEVENT BEGIN:VEVENT UID:TU1965042103 DTSTAMP:20260413T075737Z SUMMARY:Transport of beads\, bubbles and droplets in cylindrical microchann el : The role of inertia and deformations (Jean Cappello (Institut Lumièr e Matière\, Lyon)) DESCRIPTION:Who: Jean Cappello (Institut Lumière Matière\, Lyon)\n\nWhen transported in microchannels at intermediate Reynolds number\, beads\, dro plets or bubbles show interesting dynamics such as lateral migration. For rigid beads this migration is solely induced by inertial forces which lead to lateral motion of the particle until it reaches an equilibrium uncente red position in the microchannel. Transport of deformable objects as dropl ets or bubbles is even richer as the coupling between deformation and the external flow results in another lateral migration force whose orientation depends on the viscosity ratio of the two phases. I will present a study in which we investigate\, both experimentally and numerically\, the veloci ty and lateral position of beads\, droplets and bubbles transported in a c ylindrical pipe. By varying the object size\, the viscosity ratio\, the de nsity\, the Reynolds number and the capillary number\, we offer an exhaust ive parametric study exploring various dynamics from the non-deformable vi scous regime to the deformable inertial regime\, thus enabling us to highl ight the sole and combined roles of inertia and capillary effects on later al migration. Then\, focusing on the specific case of bubbles\, we further identify an intriguing regime at large deformations in which bubbles trav el faster than the maximum velocity of the carrier flow. We rationalize th is behavior in the limit of large bubbles and show that it originates from a reduction of the hydraulic resistance of the multiphase system. Finally \, we determine the key parameters governing the onset of this “superfas t” regime and demonstrate that it occurs only within a limited range of capillary and Reynolds numbers.\n\nContact: Elise Lorenceau\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260126T110000 DTEND;TZID=Europe/Paris:20260126T120000 CREATED:20251006T082706Z LAST-MODIFIED:20260113T144059Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1965042103 X-TEAMUP-WHO:Jean Cappello (Institut Lumière Matière\, Lyon) END:VEVENT BEGIN:VEVENT UID:TU2022483822 DTSTAMP:20260413T075737Z SUMMARY:[Young Researchers Only] VSS presentations: UGA reporting unit || L IPHY référents égalité (Marine DELMOTTE || Romain MARI\, Samantha MICC IULLA) DESCRIPTION:Who: Marine DELMOTTE || Romain MARI\, Samantha MICCIULLA\n\nThi s exceptional seminar aims to provide young researchers in the lab with ba sic and practical information about gender-based and sexual violence (GBSV ) and gender equality\, while helping to foster a respectful and supportiv e working environment for everyone. Representatives from UGA’s Vice Pres idency for Equality\, Parity\, and Non-Discrimination (DGD RH)\, together with the laboratory’s Equality Representatives\, were invited to introdu ce themselves\, share their current projects\, and provide key information on GBSV and gender equality.\n\n**Presentation of UGA’s reporting unit* *\n\n*Marine DELMOTTE - (DGD RH)*\n\nThis presentation will introduce the university’s reporting unit\, outlining its role\, procedures\, and avai lable support\, while also providing an overview of UGA’s initiatives\, tools\, and resources aimed at promoting gender equality and preventing di scrimination across the university community.\n\n**Presentation of LIPHY's référents égalité**\n\n*Romain MARI\, Samantha MICCIULLA (PSM\, MODI) *\n\nThis presentation will introduce the laboratory’s Equality Officers and highlight their ongoing activities and new initiatives\, aimed at add ressing gender bias and discrimination within the laboratory.​\n\n LOCATION:Conference Room (Liphy) CATEGORIES:Séminaire des non-permanents CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260130T101500 DTEND;TZID=Europe/Paris:20260130T120000 CREATED:20260112T092105Z LAST-MODIFIED:20260128T035948Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2022483822 X-TEAMUP-WHO:Marine DELMOTTE || Romain MARI\, Samantha MICCIULLA X-TEAMUP-WHERE:Conference Room (Liphy) END:VEVENT BEGIN:VEVENT UID:TU2009129871 DTSTAMP:20260413T075737Z SUMMARY:Continuum des financements des projets de valorisation (Sara Matyas (CNRS Innovation)) DESCRIPTION:Who: Sara Matyas (CNRS Innovation)\n\nLes financements de valor isation sont nombreux\, chacun avec ses guichets\, ses règles et ses crit ères… Et si on éclaircissait ce sujet ensemble ? À partir d’exemple s concrets\, nous parcourrons les différents chemins possibles pour valor iser un projet de recherche\, depuis l’idée fondamentale jusqu’à sa valorisation. Vous verrez que la start‑up n’est qu’une option parmi d’autres. L'objectif : décoder clairement les informations essentielles à retenir pour chaque type de financement et comprendre la dynamique du continuum (Pré‑maturation CNRS\, Pré‑maturation PUI\, Maturation SAT T\, programme RISE\, BTF Lab\, Incubation\, Transfert\, Licensing…).\n\n Contact: Bahram Houchmandzadeh\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260202T110000 DTEND;TZID=Europe/Paris:20260202T120000 CREATED:20251217T111942Z LAST-MODIFIED:20260127T143103Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2009129871 X-TEAMUP-WHO:Sara Matyas (CNRS Innovation) END:VEVENT BEGIN:VEVENT UID:TU2001007913 DTSTAMP:20260413T075737Z SUMMARY:Understanding DNA replication dynamics in the archaea Haloferax vol canii (Roxane Lestini and Nicolas Olivier (Laboratoire d'Optique et Biosci ences\, Palaiseau)) DESCRIPTION:Who: Roxane Lestini and Nicolas Olivier (Laboratoire d'Optique et Biosciences\, Palaiseau)\n\nArchaea provide a simplified yet highly inf ormative model for deciphering the complex regulatory networks governing D NA replication and origin firing. Among them\, Haloferax volcanii has a ci rcular chromosome with four active replication origins distributed across a 3.5 Mb DNA molecule and exhibit some distinctive properties\, such as a heterogeneous polyploidy\, carrying 10–18 copies of its genome.\n\nHow t hese highly polyploid organisms regulate the activation and timing of thei r multiple replication origins in coordination with cell growth and divisi on remains an open question. To address this question\, we developed a mul tiscale approach\, implementing the STORM technique in archaea for the fir st time\, Marker Frequency Analysis by sequencing (MFA-seq) to capture the global replication profile at the population level\, and fluorescence in situ hybridization (FISH) to explore ploidy variation.\n\nOur findings rev eal\, with an unprecedented resolution of ~30 nm\, new insights into the s patial regulation of replication foci\, demonstrating their organization i nto clusters. We further investigated DNA replication dynamics under varyi ng growth conditions\, revealing a reduction in replication foci number th at correlates with decreased replication rates and DNA content. By contras t\, altering the replication initiation mode—by inactivating all four re plication origins—does not disrupt the overall replication dynamics.\n\n By integrating these techniques\, we aim to characterize the replication p rogram in H. volcanii and gain a deeper understanding of its regulation.\n \nContact: Delphine Débarre\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260216T110000 DTEND;TZID=Europe/Paris:20260216T120000 CREATED:20251203T193111Z LAST-MODIFIED:20260109T092254Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2001007913 X-TEAMUP-WHO:Roxane Lestini and Nicolas Olivier (Laboratoire d'Optique et B iosciences\, Palaiseau) END:VEVENT BEGIN:VEVENT UID:TU2045923369 DTSTAMP:20260413T075737Z SUMMARY:HDR Pierre RECHO (Pierre RECHO) DESCRIPTION:Who: Pierre RECHO\n\n**Mechanics of cells and living tissues**\ n\nMy broad goal is to develop and study mechanical models to understand h ow cells control their shape\, volume and motility to perform collective t asks and self-organize into tissues. These functions play a crucial role i n many biological phenomena including wound healing\, inflammation\, remod eling of connecting tissues\, rebuilding of damaged structures and formati on of metastases in cancer. The aim of my research is to embed the cell’ s active functions within the framework of passive rheology while respecti ng the overarching principles of thermodynamics to formulate constitutive laws for cellular material. This in turn opens new boundary-value problems in continuum mechanics\n\nJury composition:\n\n•Bertrand Fourcade (LiPh y) Président\n\n•Alice Nicolas(LTM) Rapportrice\n\n•Pasquale Ciarlett a (MOX) Rapporteur\n\n•Hélene Delanoe-Ayari (ILM) Rapportrice\n\n•Ang élique Stéphanou(TIMC) Examinatrice\n\n•Davide Ambrosi (DISMA) Examina teur\n\n•Matthieu Caruel (MSME) Examinateur\n\n CATEGORIES:Soutenances CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260226T140000 DTEND;TZID=Europe/Paris:20260226T150000 CREATED:20260219T105925Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2045923369 X-TEAMUP-WHO:Pierre RECHO END:VEVENT BEGIN:VEVENT UID:TU2037005883 DTSTAMP:20260413T075737Z SUMMARY:[Young Researchers Only]: Modeling the emission spectra of polycycl ic aromatic hydrocarbons by recurrent fluorescence || On the physico-chemi stry of polyvinyl butyral: Elegance behind complexity. (Borja DAMIEN - (Ph D\, PSM) || Arauz Moreno CARLOS - (Post-Doc\, OPTIMA)) DESCRIPTION:Who: Borja DAMIEN - (PhD\, PSM) || Arauz Moreno CARLOS - (Post- Doc\, OPTIMA)\n\n**Modeling the emission spectra of polycyclic aromatic hy drocarbons by recurrent fluorescence**\n\n *Borja DAMIEN - (PhD\, PSM)*\n\ nThe presence of polycyclic aromatic hydrocarbons (PAHs) in interstellar m edium (ISM) is supported by the observation of aromatic infrared bands in emission spectra\, and the detection of several individual PAH species. Th e importance of recurrent fluorescence (RF) in their relaxation process co uld significantly increase their stability in such highly ionized environm ents. I present a statistical model of relaxation by RF\, including Duschi nsky rotation and Herzberg-Teller effects as well as a full account of vib rational progressions\, and its application to naphthalene\, anthracene\, and pyrene cations. For these highly symmetric molecules\, the low energy symmetry-forbidden electronic transitions are predicted to contribute more to RF than the traditionally considered\, higher energy\, non-forbidden t ransitions. This unexpected contribution could increase the cooling effici ency of PAHs and their stability under the highly ionized conditions of th e ISM.\n\n---\n\n**On the physico-chemistry of polyvinyl butyral: Elegance behind complexity.**\n\n*Arauz Moreno CARLOS - (Post-Doc\, OPTIMA)*\n\nPo lyvinyl butyral (PVB) is an amorphous polymer typically used in laminated safety glass or solar panels. In both cases\, a thin PVB sheet serves as a n adhesive between two layers of glass. While highly relevant industrially \, PVB polymers remain poorly understood at a fundamental level\, despite their interesting chemistry and equally appealing physical properties. In this talk\, I will discuss recent advances in the understanding of PVB pol ymers which link chemistry to macroscopic properties\, such as rheology\, water transport and clustering\, as well as dynamic bubbling behavior – all key properties that impact the performance of glass assemblies with PV B polymers.\n\n LOCATION:Conference Room CATEGORIES:Séminaire des non-permanents CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260227T110000 DTEND;TZID=Europe/Paris:20260227T120000 CREATED:20260204T123726Z LAST-MODIFIED:20260225T145556Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2037005883 X-TEAMUP-WHO:Borja DAMIEN - (PhD\, PSM) || Arauz Moreno CARLOS - (Post-Doc\ , OPTIMA) X-TEAMUP-WHERE:Conference Room ATTACH:https://files.teamup.com/16073145/attachment/01KJAKGSSAE803ZR36NEDCA FG6/tot_abstract.png?hash=7cf375cda2b8bd839034f279879d7adc843bb2655d168039 eba6b84ed4eecef0 ATTACH:https://files.teamup.com/16073145/attachment/01KJAKGSSXY9GYM7MTS80ET YC8/Damien_pic.jpg?hash=2f886c843173e520d0c3ddc5585a0ccf791d2b741368ff0d0c 2a8f0a3ab76264 ATTACH:https://files.teamup.com/16073145/attachment/01KJAKGSV7QSKJ8AW4SSJ5E FV0/CArauz.jpg?hash=fde0ff68bc992909e64c23eaae3ee617073aa23a3368b2c89d727a bf19ee2f6f END:VEVENT BEGIN:VEVENT UID:TU2018905838 DTSTAMP:20260413T075737Z SUMMARY:Ultrafast imaging of membrane potential and Ca2+ transients in brai n slices from individual neurons and networks (Marco Canepari) DESCRIPTION:Who: Marco Canepari\n\nThe brain slice is a living tissue\, kep t under physiological conditions for up to 6 hours\, where neurons and loc al circuitries are preserved as *in vivo*. In this preparation\, it possib le to inject Ca2+ indicators and voltage sensitive dyes (VSDs) into indivi dual neurons and perform ultrafast (5-40 kHz) imaging to record membrane p otential (Vm) and Ca2+ transients\, associated with stimulated activity\, in specific sub-cellular compartments such as axons\, dendrites and synapt ic spines. Ca2+ indicators and VSDs can be also loaded in the whole slice\ , losing the ability to resolve single cells but gaining the possibility t o monitor network activity. Vm imaging allows recording action potentials and synaptic potentials while Ca2+ influx\, triggered by Vm signals\, can be imaged and correlated with electrical activity. In fundamental neurosci ence\, this approach permits the unravelling of complex ion channels syner gies as well as the interactions with other molecules underlying neuronal function. In preclinical research\, the same strategy allows untangling dy sfunctions caused by genetic mutations in animal models of human disease. Finally\, combining Vm and Ca2+ imaging is a powerful tool to investigate the effect of drugs on neuronal excitability\, synaptic transmission and g lobal network activity. In the project *SynBin*\, we will use our high-res olution imaging approaches to explore diversity of synaptic spines in the same cerebellar Purkinje neuron. This project challenges classical learnin g theories assuming that synapses of a given type are identical except for variations of receptor numbers resulting from plasticity\, whereas eviden ce suggests that synapses have specific molecular identities\, implying no vel hypotheses regarding the mechanisms of synaptic computations\, plastic ity and their role in learning and memory. In the project *Chlorzowill*\, we will study an animal model of the Williams-Beuren syndrome\, a rare gen etic disease caused by deletion of several contiguous genes resulting in n eurological and cardiovascular alterations. Grounded on the evidence that the disease is associated with the down-regulation of BK K+ channels\, we will explore neuronal excitability on the animal model and the potential t herapeutic effect of chlorzoxazone targeting this type of channels. Finall y\, whole-slice combined Vm and Ca2+ imaging can be exploited to rapidly a nd efficiently assess the acute effects of drugs in the long industrial le ad-selection process that precedes clinical trials. A technology transfer project is ongoing on this topic.\n\n CATEGORIES:Séminaires internes CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260305T110000 DTEND;TZID=Europe/Paris:20260305T120000 CREATED:20260106T133928Z LAST-MODIFIED:20260204T184403Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2018905838 X-TEAMUP-WHO:Marco Canepari END:VEVENT BEGIN:VEVENT UID:TU2053912100 DTSTAMP:20260413T075737Z SUMMARY:[Young Researchers Only]: Mitochondrial mechano-remodeling​. || S ubstrate cleaning by polymer coat\, crack & peel​. (Eloina CORRADI - (Po st-Doc\, MicroTiss) || Mona MOUKRATI - (PhD\, MODI)) DESCRIPTION:Who: Eloina CORRADI - (Post-Doc\, MicroTiss) || Mona MOUKRATI - (PhD\, MODI)\n\n**Mitochondrial mechano-remodeling​.**\n\n *Eloina CORR ADI - (Post-Doc\, MicroTiss)*\n\nMitochondria are double-membrane organell es that sustain the bioenergetic metabolism of cells by producing ATP at t he level of the cristae\, convoluted folds of the inner membrane. ATP prod uction efficiency and mitochondrial morphology\, including cristae archite cture\, are tightly linked. Consequently\, by being coupled to mitochondri al function\, the reshaping of mitochondria across spatial scales regulate s the cellular bioenergetic and metabolic states. Mechanical stimuli have recently been shown to modulate cellular metabolism\, thus impacting physi ological (e.g. cell migration\, proliferation\, death) and pathological (e .g. cancer progression) processes. ​\n\nHere\, using a unique biomechani cal tool to stretch cells\, we show that mechanical stimulation drasticall y re-shape mitochondria across spatial scale\, deforming and modulating bo th external and internal architecture\, impacting cell metabolism. ​\n\n ---\n\n**Substrate cleaning by polymer coat\, crack &\; peel​.**\n\n* Mona MOUKRATI- (PhD\, MODI)*\n\nThe continuous miniaturization of microele ctronic devices imposes increasingly stringent requirements on surface cle anliness\, as nanoparticles above 10 nm critically threaten device perform ance. Conventional cleaning methods often damage delicate nanostructures o r lack sufficient nanoscale efficiency.​\n\nThis work investigates polym er-film-based cleaning via controlled delamination of polymethyl methacryl ate (PMMA)\, triggered by crack formation when the coated wafer is immerse d in ethanol. The influence of experimental parameters on crack morphology and propagation is systematically examined to better understand the under lying cracking mechanism. Applied to ceria-contaminated silicon wafers\, t his crack-induced delamination process achieves over 80% particle removal. ​\n\n​\n\n LOCATION:Conference Room CATEGORIES:Séminaire des non-permanents CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260313T110000 DTEND;TZID=Europe/Paris:20260313T120000 CREATED:20260304T073617Z LAST-MODIFIED:20260310T094107Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2053912100 X-TEAMUP-WHO:Eloina CORRADI - (Post-Doc\, MicroTiss) || Mona MOUKRATI - (Ph D\, MODI) X-TEAMUP-WHERE:Conference Room ATTACH:https://files.teamup.com/16073145/attachment/01KKBHXB3FE4FTM6GHFK447 D5S/MOUKRATI%20Mona%20B.jpg?hash=f7d0a6d453e86a72125f4cccf99f724aa2824b18b 5bce1011d71cb71583990db ATTACH:https://files.teamup.com/16073145/attachment/01KKBHXB46QF30RDK5EMA53 A62/fig_abstract.png?hash=ab7a17127b74bc145f646aaaf8a99d845359d800878d9284 789e7e65fb72c3fe ATTACH:https://files.teamup.com/16073145/attachment/01KKBHXB4S2DSN197EC0DTP 6PV/Eloina_portrait.jpeg?hash=30c20ba18c5e957b8de3d710d11429bfd83f6fa87355 b241e7d66e7491b43098 END:VEVENT BEGIN:VEVENT UID:TU1947824725 DTSTAMP:20260413T075737Z SUMMARY:A circadian clock in Bacillus subtilis (Martha Merrow (LMU Munich\, Germany)) DESCRIPTION:Who: Martha Merrow (LMU Munich\, Germany)\n\nThe circadian cloc k is a molecular machine that is present in each one of our cells\, direct ing diverse processes in a cell(developmentally)-specific manner. The natu ral state of the clock is ‘entrainment’\, namely through synchronizati on with zeitgeber signals (such as the light/dark cycle) in the environmen t. Once moved to constant conditions\, a free running rhythm of approximat ely 24h can be observed\, demonstrating the endogenous nature of the clock . One can understand how the clock relates to our lives by noting the timi ng of the sleep wake cycle: this is determined by the interaction of the b iological (circadian) oscillator and the external zeitgeber cycle. Disrupt ing the clock in humans and mice leads to increased cancers\, metabolic di sease and decreased cognitive performance\, likely through misexpression o f key regulators. The circadian clock is an essential aspect of biology an d its function can be regarded as a biophysical phenomenon.\n\nCircadian c locks have been described in all kingdoms of life except for the Eubacteri a – until very recently. I will discuss the circadian clock in the model prokaryote\, Bacillus subtilis. We observe rhythms in gene expression\, i n colony morphology on agar\, and in metabolism and in planktonic cultures . The circadian transcriptome shows pervasive regulation of gene expressio n by the biological clock\, even more extensively than sigma factors. The clock is thus a major regulatory phenomenon in this bacterium. Our work be gs the questions ‘what is the same as clocks in higher organisms?’ and ‘what is different?’.\n\nContact: Irina Mihalcescu\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260316T110000 DTEND;TZID=Europe/Paris:20260316T120000 CREATED:20250908T130627Z LAST-MODIFIED:20260227T075749Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1947824725 X-TEAMUP-WHO:Martha Merrow (LMU Munich\, Germany) END:VEVENT BEGIN:VEVENT UID:TU1984934570 DTSTAMP:20260413T075737Z SUMMARY:Retours d'expérience de l'équipe BIOP sur le cahier de laboratoir e électronique eLabFTW (Catherine Bouchenot) DESCRIPTION:Who: Catherine Bouchenot\n\nDepuis juin 2022\, le CNRS préconi se l'utilisation de cahier de laboratoire électronique (CLE) et propose à cet effet une offre de service basée sur l'outil **elabFTW**.\n\nCe ch oix fait suite à un groupe de travail démarré en 2020 pour identifier d es solutions électroniques adaptées aux pratiques de la recherche en pre nant en compte la diversité des activités du CNRS tout en assurant la m émoire\, la traçabilité\, la sécurité\, la confidentialité et la pé rennité des résultats de recherche et tout en respectant les exigences l iées à la Science Ouverte et à la protection du patrimoine scientifique et technique de l’établissement.\n\n Sur le campus grenoblois\, GRICAD propose depuis 2020 une instance de elabFTW parmi la liste des outils mut ualisés à disposition des laboratoires du campus.\n\nAu sein du Liphy\, l'équipe BIOP s'est portée volontaire en 2023 en tant qu'équipe pilote pour l'utilisation de eLabFTW.\n\nCette présentation propose un retour d' expérience de cette équipe pilote sur l'utilisation de cet outil de CLE\ ; ce sera aussi l'occasion de présenter elabFTW et ses fonctionnalités.\ n\n CATEGORIES:Séminaires internes CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260319T110000 DTEND;TZID=Europe/Paris:20260319T120000 CREATED:20251106T154836Z LAST-MODIFIED:20260204T184653Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1984934570 X-TEAMUP-WHO:Catherine Bouchenot END:VEVENT BEGIN:VEVENT UID:TU2024869317 DTSTAMP:20260413T075737Z SUMMARY:Uncovering the forces driving the fate and shape of the extraembryo nic amnion during human gastrulation (Chloé Roffay (IMP Vienna\, Austria) ) DESCRIPTION:Who: Chloé Roffay (IMP Vienna\, Austria)\n\nExtraembryonic tis sues provide key molecular signals and mechanical support to the growing e mbryo. For instance\, the extraembryonic amnion\, which forms a fluid-fill ed sac surrounding the embryo\, was recently shown to trigger germ layer s pecification during gastrulation\, by secreting BMP ligands. Despite the k ey roles of extraembryonic tissues in embryo development\, little is still known regarding their molecular and biophysical programs\, particularly i n human. Using a 2D stem cell-based model of human gastrulation\, termed g astruloid discs\, we found that amnion cells undergo a sharp columnar-to-s quamous transition concomitantly with fate specification. Via biophysical modelling\, direct force measurements\, pharmacological and genetic pertur bations\, we showed that this morphogenetic transition is amnion-intrinsic and it is driven by active wetting\, i.e. a transition from tensile to ad hesion-dominated cellular states. Molecularly\, active wetting is implemen ted via a rewiring of cytoskeleton composition\, from actomyosin to kerati n-based cytoskeletal networks\, akin to a bistable toggle-switch in gene r egulatory networks. Strikingly\, blocking shape changes at the colony edge results both in defective cellular states in the amnion and impaired gast ruloid disc morphogenesis within the embryonic compartment. Together\, our findings establish that a cytoskeletal toggle switch couples fate specifi cation to tissue architecture in the human amnion and suggest an unexpecte dly active mechanical role for extraembryonic tissues in shaping the embry o proper.\n\nContact: Thomas Boudou\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260323T110000 DTEND;TZID=Europe/Paris:20260323T120000 CREATED:20260115T135555Z LAST-MODIFIED:20260312T135227Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2024869317 X-TEAMUP-WHO:Chloé Roffay (IMP Vienna\, Austria) END:VEVENT BEGIN:VEVENT UID:TU2059068127 DTSTAMP:20260413T075737Z SUMMARY:Role of defects in morphogenesis and wrinkling (Arthur Hernandez (L eiden University\, the Netherlands)) DESCRIPTION:Who: Arthur Hernandez (Leiden University\, the Netherlands)\n\n The emergence of a body axis is a fundamental step in the development of m ulticellular organisms. For example\, in simple systems such as Hydra\, gr owing evidence suggests that mechanical forces generated by collective cel lular activity play a central role in this process. In this seminar\, I wi ll propose a physical mechanism for axis formation based on the coupling b etween active stresses and tissue elasticity. The interplay between elasti c deformations induced by activity-generated stresses\, nematicity\, and s pherical topology results in a global condensation of forces and defects w hich defines either a bipolar or polar head-foot axis. Compact parametriza tions of the active force and flux distributions enable analytical predict ions and direct comparison with experimental data on tissue stretching of Hydra. Within this framework\, one may calculate relevant observables incl uding areal strain\, lateral pressure\, and normal displacements during mu scular contraction\, as well as the detailed structure of topological defe ct complexes in head and foot regions. Together\, these results identify a mechanical route by which active tissues can spontaneously break symmetry at the organismal scale\, suggesting a general physical principle underly ing body-axis specification during morphogenesis. Time permitting\, I will also discuss extensions of this framework towards wrinkling of active nem atic sheets where the feedback between nematic defects and spontaneous cur vature can engender a diverse morphology of wrinkle patterning.\n\nContact : Alexander Erlich\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260402T110000 DTEND;TZID=Europe/Paris:20260402T120000 CREATED:20260312T113337Z LAST-MODIFIED:20260330T075034Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2059068127 X-TEAMUP-WHO:Arthur Hernandez (Leiden University\, the Netherlands) END:VEVENT BEGIN:VEVENT UID:TU2036186932 DTSTAMP:20260413T075737Z SUMMARY:Mechanical signaling through motility before settlement (Manon Vale t (MC2)) DESCRIPTION:Who: Manon Valet (MC2)\n\nTo complete their life cycles\, many marine invertebrate species undergo metamorphosis\, a key transition from their larval\, planktonic stage to the adult benthic form. When\, where\, and how larvae choose to initiate the process remain debated. To address t his matter\, I propose to study the coupling between ciliary and neuronal activity in sea urchin larvae close to a solid/liquid interface mimicking the seabed.\n\nDuring this talk “without results”\, I will motivate th e choice of this non-conventional model system to develop an interdiscipli nary project linking developmental biology\, signalization\, and biophysic s. I will present the main ideas structuring the project and how I would l ike to conduct it at LIPhy.\n\n CATEGORIES:Séminaires internes CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260409T110000 DTEND;TZID=Europe/Paris:20260409T120000 CREATED:20260203T085229Z LAST-MODIFIED:20260407T110845Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2036186932 X-TEAMUP-WHO:Manon Valet (MC2) END:VEVENT BEGIN:VEVENT UID:TU2058428218 DTSTAMP:20260413T075737Z SUMMARY:Granular heap on an elastic membrane : statics and dynamics (Sophie Monnery (Institut Jean le Rond d’Alembert\, Paris)) DESCRIPTION:Who: Sophie Monnery (Institut Jean le Rond d’Alembert\, Paris )\n\nWhen granular material is poured onto an elastic membrane\, it forms a heap whose weight deforms the membrane. The membrane’s deformation\, i n turn\, constrains the heap’s geometry\, causing its aspect ratio to de viate from the classic triangular profile. This coupling is governed by a dimensionless number that captures the balance between the membrane’s el asticity and the granular weight in this simplified elasto-granular system . We introduce an incremental model to predict the heap’s temporal evolu tion\, accounting for its spreading and growth as mass is added.\n\nThen\, upon introducing energy into the system by vibrating the elastic support\ , grains rearrangements reshape the heap’s apex\, giving rise to new con figurations\, including a “volcano-like” profile that is more compact. At even higher vibrational amplitudes\, grains begin to detach from the b ulk and to bounce on the membrane\, with spiraling trajectories.\n\nContac t: Philippe Marmottant\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260413T110000 DTEND;TZID=Europe/Paris:20260413T120000 CREATED:20260311T133011Z LAST-MODIFIED:20260313T133458Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2058428218 X-TEAMUP-WHO:Sophie Monnery (Institut Jean le Rond d’Alembert\, Paris) END:VEVENT BEGIN:VEVENT UID:TU2069808903 DTSTAMP:20260413T075737Z SUMMARY:Young Researchers Seminar CATEGORIES:Séminaire des non-permanents CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260424T110000 DTEND;TZID=Europe/Paris:20260424T120000 CREATED:20260330T090459Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2069808903 END:VEVENT BEGIN:VEVENT UID:TU2038569180 DTSTAMP:20260413T075737Z SUMMARY:TBA (Giulio Facchini (Laboratoire Matière et Systèmes Complexes\, Paris)) DESCRIPTION:Who: Giulio Facchini (Laboratoire Matière et Systèmes Complex es\, Paris)\n\nContact: Emmanuel Siéfert\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260504T110000 DTEND;TZID=Europe/Paris:20260504T120000 CREATED:20260206T183924Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2038569180 X-TEAMUP-WHO:Giulio Facchini (Laboratoire Matière et Systèmes Complexes\, Paris) END:VEVENT BEGIN:VEVENT UID:TU2045212259 DTSTAMP:20260413T075737Z SUMMARY:Géraldine Bozec - TBD CATEGORIES:Séminaires internes CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260507T110000 DTEND;TZID=Europe/Paris:20260507T120000 CREATED:20260218T095557Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2045212259 END:VEVENT BEGIN:VEVENT UID:TU2048222636 DTSTAMP:20260413T075737Z SUMMARY:From active particles to flexible\, deformable\, and motile superst ructures : a new type of soft robot of robots (Hamid Kellay (Laboratoire O ndes et Matière d'Aquitaine\, Bordeaux)) DESCRIPTION:Who: Hamid Kellay (Laboratoire Ondes et Matière d'Aquitaine\, Bordeaux)\n\nWe study assemblies of rodlike robots made motile through sel f-vibration. When confined by circular scaffolds\, dilute assemblies of th ese rods act as a 2D gas of particles. Above a critical surface fraction\, some of the bots line up in one or more tight clusters along the corral b oundary while\, in the bulk\, gas-like behavior is retained. We find that the unified pushing of the clustered bots on the boundary can drive collec tive motion: by selecting corrals that are deformable but free to move\, w e take advantage of surface cluster formation to force the robots to work together. The deformability of the arena allows the assembly to go through narrow slits or to circumvent obstacles. Simple tasks such as pulling a l oad\, moving through an obstacle course\, or cleaning up an arena are demo nstrated. Rudimentary control of these superstructures (robots+scaffold) u sing light is also proposed.\n\nContact: Jean-Louis Barrat\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260511T110000 DTEND;TZID=Europe/Paris:20260511T120000 CREATED:20260223T144422Z LAST-MODIFIED:20260412T063901Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2048222636 X-TEAMUP-WHO:Hamid Kellay (Laboratoire Ondes et Matière d'Aquitaine\, Bord eaux) END:VEVENT BEGIN:VEVENT UID:TU2070547609 DTSTAMP:20260413T075737Z SUMMARY:HDR: Phage Display and microbial systems: the development of biorec eptors and their applications in biotechnology (Natale Scaramozzino) DESCRIPTION:Who: Natale Scaramozzino\n\nI have developed my scientific care er at the intersection of biology\, physics and biotechnology. Following t he completion of my doctoral thesis on high-risk biological viruses\, I wo rked on molecular detection methods\, with a particular focus on the small pox virus. I also contributed to the development of an automated genotypin g unit for use in forensic science. My research at LIPhy (CNRS) has centre d on using phage display to select antibodies and peptides for use in bios ensors\, including electronic noses for detecting volatile organic compoun ds and pathogens such as Campylobacter jejuni. I have also studied non-can onical DNA structures\, such as telomeric G-quadruplexes. My current proje cts combine microfluidics\, genomic engineering and modelling to improve o ur understanding of bacterial mechanisms\, including strategies for alloca ting protein resources and the dynamics of microbial consortia. These proj ects have applications in the rapid detection of pathogens\, the developme nt of biomolecules that target specific DNA structures and the optimisatio n of microbial systems for biotechnological applications. My career path r eflects a collaborative and interdisciplinary approach\, combining fundame ntal research with applied innovation.\n\n CATEGORIES:Soutenances CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260528T140000 DTEND;TZID=Europe/Paris:20260528T150000 CREATED:20260331T094511Z LAST-MODIFIED:20260413T075437Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2070547609 X-TEAMUP-WHO:Natale Scaramozzino END:VEVENT BEGIN:VEVENT UID:TU2057554366 DTSTAMP:20260413T075737Z SUMMARY:TBA (Claire Lestringant (Sorbonne Université\, Paris)) DESCRIPTION:Who: Claire Lestringant (Sorbonne Université\, Paris)\n\nConta ct: Emmanuel Siéfert\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260601T110000 DTEND;TZID=Europe/Paris:20260601T120000 CREATED:20260310T080937Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2057554366 X-TEAMUP-WHO:Claire Lestringant (Sorbonne Université\, Paris) END:VEVENT BEGIN:VEVENT UID:TU2048006478 DTSTAMP:20260413T075737Z SUMMARY:Antoine Delon - TBD X-MICROSOFT-CDO-ALLDAYEVENT:TRUE CATEGORIES:Séminaires internes CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;VALUE=DATE:20260604 DTEND;VALUE=DATE:20260605 CREATED:20260223T091152Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2048006478 END:VEVENT BEGIN:VEVENT UID:TU2061186293 DTSTAMP:20260413T075737Z SUMMARY:TBA (François Peaudecerf (Institut de Physique de Rennes)) DESCRIPTION:Who: François Peaudecerf (Institut de Physique de Rennes)\n\nC ontact: Delphine Débarre\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260907T110000 DTEND;TZID=Europe/Paris:20260907T120000 CREATED:20260316T083616Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2061186293 X-TEAMUP-WHO:François Peaudecerf (Institut de Physique de Rennes) END:VEVENT BEGIN:VEVENT UID:TU1984923542 DTSTAMP:20260413T075737Z SUMMARY:A biophysicist’s view of a biological oscillator: the circadian c lock in cyanobacteria (Irina) DESCRIPTION:Who: Irina\n\n CATEGORIES:Séminaires internes CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20260910T110000 DTEND;TZID=Europe/Paris:20260910T120000 CREATED:20251106T153136Z LAST-MODIFIED:20260407T073139Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/1984923542 X-TEAMUP-WHO:Irina END:VEVENT BEGIN:VEVENT UID:TU2072701857 DTSTAMP:20260413T075737Z SUMMARY:TBA (Joël Marthelot (IUSTI\, Marseille)) DESCRIPTION:Who: Joël Marthelot (IUSTI\, Marseille)\n\nContact: Elsa Bayar t\n\n CATEGORIES:Séminaire labo CLASS:PUBLIC TRANSP:OPAQUE SEQUENCE:0 DTSTART;TZID=Europe/Paris:20261012T110000 DTEND;TZID=Europe/Paris:20261012T120000 CREATED:20260403T170534Z URL;VALUE=URI:https://teamup.com/kspjx8oo4q8mxg7v8h/events/2072701857 X-TEAMUP-WHO:Joël Marthelot (IUSTI\, Marseille) END:VEVENT END:VCALENDAR